Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?
نویسندگان
چکیده
A great deal of evidence has revealed an important link between gut microbiota and the heart. In particular, plays a key role in onset cardiovascular (CV) disease, including heart failure (HF). HF, splanchnic hypoperfusion causes intestinal ischemia resulting translocation bacteria their metabolites into blood circulation. Among these metabolites, most is Trimethylamine N-Oxide (TMAO), which responsible, through various mechanisms, for pathological processes different organs tissues. this review, we summarise complex interaction CV particularly with respect to possible strategies influencing its composition function. Finally, highlight potential TMAO as novel prognostic marker new therapeutic target HF.
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2023
ISSN: ['1661-6596', '1422-0067']
DOI: https://doi.org/10.3390/ijms241511971